The East Lansing school says the class is its first free Massive Open Online Course and debuts in May 2013.
The Foundations of Science class makes the tongue-in-cheek promise that students will learn "to speak mumbo jumbo" and amaze their friends.
Zoologist Stephen Thomas says he and course co-creator Julie Libarkin seek to help students improve their critical thinking skills and make better decisions.
The Bill & Melinda Gates Foundation is providing $50,000 to fund the course, which will be offered worldwide. Michigan State says Thomas and Libarkin hope the class attracts at least 10,000 students.
Registration information: http://www.foundations-of-science.zoology.msu.edu