The trade mission begins Saturday and ends Tuesday. The group is meeting with business and government leaders, including President Juan Manuel Santos and top ministers.
The South American nation has a growing presence life sciences — including medical device manufacturers — and clean energy.
The U.S. signed a trade agreement hoping to expand American exports to Colombia by more than $1 billion. Massachusetts exported about $81.5 million to Colombia last year, 33rd among the state's trade partners.
The governor's office says the trade mission is expected to cost about $180,000. Part of that will be picked up by private businesses.
Patrick has led trade missions to Brazil, Chile, Israel, England and China. His wife, Diane, will accompany him this time.
