"All of those justices can see the obvious implications for religious freedom here, and I think it's possible that this is decided not just 5-4 in our favor, but perhaps 6-3 or even 7-2," he said during an interview with conservative journalist Guy Benson on "The Hugh Hewitt Show."
The court heard arguments in the case Tuesday.
Benson questioned Lee about the complaints from pro-choice activists, accusing Republicans of trying to ban birth control or limit access to contraception.
"No, there isn't, there is not now, there will not be tomorrow, or next year or 10 years from now, and there hasn't been to my knowledge since I've been not only in the Senate -- to my knowledge since I've been alive -- to do any of those things," he said.
Lee pointed out that it wasn't anyone's business whether or not a woman decided to use birth control.
"This notion that anyone in our party wants to interfere with any woman's, any couple's decision with regard to when to have children with regard to contraception is absurd," Lee said. "It is a patent falsehood lie and needs to be called out as such."